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1

Extramural cross-validation of the mayo primary biliary cirrhosis survival model establishes its generalizability

Patricia M. Grambsch, E. Rolland Dickson, Marshall Kaplan, Gene Lesage, Thomas R. Fleming, Alice L. Langworthy

Journal:

Year:

1989

Language:

english

File:

PDF, 517 KB

english, 1989

2

Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats

Gianfranco Alpini, Shannon Glaser, Leonardo Baiocchi, Heather Francis, Xuefeng Xia, Gene LeSage

Journal:

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

3

Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver

Gene D. LeSage, Antonio Benedetti, Shannon Glaser, Luca Marucci, Ziga Tretjak, Alessandra Caligiuri, Rebecca Rodgers, Jo Lynne Phinizy, Leonardo Baiocchi, Heather Francis, John Lasater, Laura Ugili, G

Journal:

Year:

1999

Language:

english

File:

PDF, 886 KB

english, 1999

4

Functional heterogeneity of the intrahepatic biliary epithelium

Noriatsu Kanno, Gene LeSage, Shannon Glaser, Domenico Alvaro, Assistant Professor Gianfranco Alpini

Journal:

Year:

2000

Language:

english

File:

PDF, 241 KB

english, 2000

5

Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3β pathway

Lin Chen, Yi Zhang, Xiuli Sun, Hui Li, Gene LeSage, Avani Javer, Xiumei Zhang, Xinbing Wei, Yulin Jiang, Deling Yin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

6

Regulation of cholangiocyte proliferation

Gene LeSage, Shannon Glaser, Gianfranco Alpini

Journal:

Liver International

Year:

2001

Language:

english

File:

PDF, 270 KB

english, 2001

7

β-Arrestin 2 regulates toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β

Hui Li, Xiuli Sun, Gene LeSage, Yi Zhang, Zhihou Liang, Jixiang Chen, Gregory Hanley, Lei He, Shenggang Sun, Deling Yin

Journal:

Year:

2010

Language:

english

File:

PDF, 348 KB

english, 2010

8

Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice

Yoshiyuki Ueno, Gianfranco Alpini, Kaichiro Yahagi, Noriatsu Kanno, Yuki Moritoki, Koji Fukushima, Shannon Glaser, Gene LeSage, Tooru Shimosegawa

Journal:

Liver International

Year:

2003

Language:

english

File:

PDF, 813 KB

english, 2003

9

Gastrin Inhibits Cholangiocyte Growth in Bile Duct–Ligated Rats by Interaction With Cholecystokinin-B/Gastrin Receptors viad -myo-Inositol 1,4,5-Triphosphate–, Ca2+-, and Protein Kinase C α–Dependent Mechanisms

Shannon Glaser, Antonio Benedetti, Luca Marucci, Domenico Alvaro, Leonardo Baiocchi, Noriatsu Kanno, Alessandra Caligiuri, Jo Lynne Phinizy, Usha Chowdury, Emanuela Papa, Gene LeSage, Gianfranco Alpin

Journal:

Year:

2000

Language:

english

File:

PDF, 366 KB

english, 2000

10

Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes

Gianfranco Alpini, Yoshiyuki Ueno, Shannon S. Glaser, Marco Marzioni, Jo Lynne Phinizy, Heather Francis, Gene LeSage

Journal:

Year:

2001

Language:

english

File:

PDF, 337 KB

english, 2001

11

Stimulation of α2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities

Noriatsu Kanno, Gene LeSage, Jo Lynne Phinizy, Shannon Glaser, Heather Francis, Gianfranco Alpini

Journal:

Year:

2002

Language:

english

File:

PDF, 375 KB

english, 2002

12

Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity

Gene D. LeSage, Luca Marucci, Domenico Alvaro, Shannon S. Glaser, Antonio Benedetti, Marco Marzioni, Tushar Patel, Heather Francis, Jo Lynne Phinizy, Gianfranco Alpini

Journal:

Year:

2002

Language:

english

File:

PDF, 390 KB

english, 2002

13

Book reviews

Gene D. LeSage, Gary L. Davis

Journal:

Digestive Diseases and Sciences

Year:

1982

Language:

english

File:

PDF, 106 KB

english, 1982

14

HIV-1 gp120 primes lymphocytes for opioid-induced, β-arrestin 2-dependent apoptosis

Jonathan Moorman, Yi Zhang, Bindong Liu, Gene LeSage, Yangchao Chen, Charles Stuart, Deborah Prayther, Deling Yin

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 379 KB

english, 2009

15

Chronic stress promotes lymphocyte reduction through TLR2 mediated PI3K signaling in a β-arrestin 2 dependent manner

Hui Li, Lin Chen, Ying Zhang, Gene LeSage, Yi Zhang, Yan Wu, Gregory Hanley, Shenggang Sun, Deling Yin

Journal:

Journal of Neuroimmunology

Year:

2011

Language:

english

File:

PDF, 532 KB

english, 2011

16

Toll-like receptor 2 is required for opioids-induced neuronal apoptosis

Yi Li, Hui Li, Yi Zhang, Xiuli Sun, Gregory A. Hanley, Gene LeSage, Ying Zhang, Shenggang Sun, Ying Peng, Deling Yin

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 1.31 MB

english, 2010

17

cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway

Heather Francis, Shannon Glaser, Yoshiyuki Ueno, Gene LeSage, Luca Marucci, Antonio Benedetti, Silvia Taffetani, Marco Marzioni, Domenico Alvaro, Julie Venter, Ramona Reichenbach, Giammarco Fava, Jo L

Journal:

Journal of Hepatology

Year:

2004

Language:

english

File:

PDF, 457 KB

english, 2004

18

Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice

Yi Zhang, Hui Li, Yi Li, Xiuli Sun, Mengyang Zhu, Gregory Hanley, Gene LeSage, Deling Yin

Journal:

Neuroscience Letters

Year:

2011

Language:

english

File:

PDF, 371 KB

english, 2011

19

Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis

Nanchang Xie, Hui Li, Dailin Wei, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth Ferslew, Lei He, Zhaofu Chi, Deling Yin

Journal:

Neuropharmacology

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

20

α-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+- and PKC-dependent stimulation of cAMP

Gene D. LeSage, Domenico Alvaro, Shannon Glaser, Heather Francis, Luca Marucci, Tania Roskams, Jo Lynne Phinizy, Marco Marzioni, Antonio Benedetti, Silvia Taffetani, Barbara Barbaro, Giammarco Fava, Y

Journal:

Year:

2004

Language:

english

File:

PDF, 566 KB

english, 2004

21

Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

Gianfranco Alpini*, ‡, §, Shannon S. Glaser*, Yoshiyuki Ueno¶, Rebecca Rodgers*, Jo Lynne Phinizy*, Heather Francis*, Leonardo Baiocchi*, Leigh A. Holcomb§, ∥, Alessandra Caligiuri*, Gene D. LeSage*

Journal:

Gastroenterology

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

22

Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct–ligated rats

Gene LeSage*, Domenico Alvaro‡, Antonio Benedetti§, Shannon Glaser∥, Luca Marucci§, Leonardo Baiocchi¶, Wendy Eisel#, Alessandra Caligiuri*, Jo Lynne Phinizy∥, Rebecca Rodgers¶, Heather Francis∥, Gian

Journal:

Gastroenterology

Year:

1999

Language:

english

File:

PDF, 256 KB

english, 1999

23

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats

Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser, Mario Angelico, Domenico Alvaro, Heather Francis, Marco Marzioni, Jo Lynne Phinizy, Barbara Barbaro, Gene LeSage

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 405 KB

english, 2003

24

Gamma-interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis

Gianfranco Alpini, Ivan Elias, Shannon S. Glaser, Rebecca E.D. Rodgers, Jo Lynne Phinizy, Willie E. Robertson, Heather Francis, John Lasater, Mark Richards, Gene D. LeSage

Journal:

Journal of Hepatology

Year:

1997

Language:

english

File:

PDF, 1.29 MB

english, 1997

25

Regulation of cholangiocyte bile secretion

Leonardo Baiocchi, Gene LeSage, Shannon Glaser, Gianfranco Alpini

Journal:

Journal of Hepatology

Year:

1999

Language:

english

File:

PDF, 1.66 MB

english, 1999

26

Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+-dependent PKC isoforms

Shannon Glaser, Domenico Alvaro, Yoshiyuki Ueno, Heather Francis, Marco Marzioni, Jo Lynne Phinizy, Brandy Baumann, Maria Grazia Mancino, Julie Venter, Gene LeSage, Gianfranco Alpini

Journal:

Liver International

Year:

2003

Language:

english

File:

PDF, 244 KB

english, 2003

27

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

Gianfranco Alpini, Leonardo Baiocchi, Shannon Glaser, Yoshiyuki Ueno, Marco Marzioni, Heather Francis, Jo Lynne Phinizy, Mario Angelico, Gene LeSage

Journal:

Year:

2002

Language:

english

File:

PDF, 471 KB

english, 2002

28

Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes

Xia, Xuefeng, Jung, Dongju, Webb, Paul, Zhang, Aijun, Zhang, Bin, Li, Lifei, Ayers, Stephen D., Gabbi, Chiara, Ueno, Yoshiyuki, Gustafsson, Jan-Åke, Alpini, Gianfranco, Moore, David D., LeSage, Gene D

Journal:

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

29

Bile acid stimulation of small bile duct proliferation requires de novo expression of the apical bile acid transporter (ABAT)

Gianfranco Alpini, Shannon Glaser, Jo Lynne Phinizy, Noriatsu Kanno, Heather Francis, Mikel Ludvik, Gene Lesage

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

30

Regulation of cholanglocyte apical bile acid transporter (ABAT) activity by biliary bile acids: Different potential compensatory changes for intrahepatic and extrahepatic cholestasis

Gianfranco Alpini, Shannon Glaser, Jo Lynne Phinizy, Noriatsu Kanno, Heather Francis, Mikel Ludvik, Gene Lesage

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 176 KB

english, 2001

31

The growth of two human cholangiocarcinoma cell lines is inhibited by alpha-2 adrenergic agonists by a cAMP-dependent mechanism through the inhibition of Raf-1 and MAPK systems

Noriatsu Kanno, Gene Lesage, Shannon Glaser, Jo Lynne Phinizy, Mikel Ludvik, Gianfranco Alpini

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 187 KB

english, 2001

32

CDC42 is Required for Intestinal Stem Cell Self-Renewal but Not Differentiation

Lei Chen, Gene LeSage

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 43 KB

english, 2011

33

Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-α

Noriatsu Kanno, Shannon Glaser, Usha Chowdhury, Jo Lynne Phinizy, Leonardo Baiocchi, Heather Francis, Gene LeSage, Gianfranco Alpini

Journal:

Journal of Hepatology

Year:

2001

Language:

english

File:

PDF, 1.28 MB

english, 2001

34

856 Bile acid feeding protects cholangiocytes from hepatic artery ligation-induced apoptosis by stimulating cholangiocyte VEGF secretion through a PI3K/AKT dependent mechanism

Shannon Glaser, Heather Francis, Silvia Taffetani, Jo Lynne Phinizy, Domenico Alvaro, Eugenio Gaudio, Trenton Horst, Marco Marzioni, Gene LeSage, Brandy Baumann, Julie Venter, Giammarco Fava, Yoshiyuk

Journal:

Year:

2003

Language:

english

File:

PDF, 255 KB

english, 2003

35

Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase–dependent pathway in rats

Gianfranco Alpini, Shannon Glaser, Domenico Alvaro, Yoshiyuki Ueno, Marco Marzioni, Heather Francis, Leonardo Baiocchi, Tonino Stati, Barbara Barbaro, Jo Lynne Phinizy, Jeremy Mauldin, Gene LeSage

Journal:

Gastroenterology

Year:

2002

Language:

english

File:

PDF, 460 KB

english, 2002

36

Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes Through Release of ATP Into Bile

Noritaka Minagawa, Jun Nagata, Kazunori Shibao, Anatoliy I. Masyuk, Dawidson A. Gomes, Michele A. Rodrigues, Gene Lesage, Yasutada Akiba, Jonathan D. Kaunitz, Barbara E. Ehrlich, Nicholas F. Larusso,

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 3.25 MB

english, 2007

37

Essential role of IL-10/STAT3 in chronic stress-induced immune suppression

Hu, Dan, Wan, Lei, Chen, Michael, Caudle, Yi, LeSage, Gene, Li, Qinchuan, Yin, Deling

Journal:

Brain, Behavior, and Immunity

Year:

2014

Language:

english

File:

PDF, 1.92 MB

english, 2014

38

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

Jung, Dongju, York, J. Philippe, Wang, Li, Yang, Chaofeng, Zhang, Aijun, Francis, Heather L., Webb, Paul, McKeehan, Wallace L., Alpini, Gianfranco, LeSage, Gene D., Moore, David D., Xia, Xuefeng

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

39

Cost-of-illness for hepatitis C patients is greater than baseline medical costs and increases with disease severity

Ghaleb, Aline, Sherer, Atkinson, Burk, Kimberley, Culp, Kim, Lesage, Gene

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

40

Bile acid absorption in isolated bile duct units (IBDU) is primarily due to the apical bile acid transporter

Alpini, Gianfranco, Glaser, Shannon, Phinizy, Jo Lynne, Hofmann, Alan F., LeSage, Gene

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 199 KB

english, 2000

41

Cystadenoma of the Proximal Common Hepatic Duct: The Use of Abdominal Ultrasonography and Transhepatic Cholangiography in Diagnosis

NAGORNEY, DAVID M., LeSAGE, GENE D., CHARBONEAU, J. WILLIAM, McGOUGH, PAUL F.

Journal:

Mayo Clinic Proceedings

Year:

1984

Language:

english

File:

PDF, 548 KB

english, 1984

42

Camp stimulates secretory and proliferative capacity of the rat intrahepatic biliary epithelium through the PKA system

LeSage, Gene, Glaser, Shannon, Alvaro, Domenico, Kanno, Noriatsu, Phinizy, Jo Lynne, Chowdury, Usha, Alpini, Gianfranco

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 201 KB

english, 2000

43

The alpha-2 adrenergic agonist, UK 14,304, inhibits growth andincreases apoptosis of the cholangio-carcinoma cell line, Mz-Cha-1, through camp but not Ca2+-dependent mechanisms

Kanno, Noriatsu, Glaser, Shannon, Chowdhury, Usha, Phinizy, Jo Lynne, Francis, Heather, LeSage, Gene, Alpini, Gianfranco

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 199 KB

english, 2000

44

Autocrine TGF-beta signaling in cholangiocytes reduces impaired bile duct repair due to TNF

Xia, Xuefeng, Shentu, Shujun, Roundtree, Marlon, Najam, Azmeena, Lesage, Gene

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 257 KB

english, 2003

45

Development and characterization of secretory functions of a rat cholangiocyte cell culture system

Phinizy, Jo Lynne, Glaser, Shannon, Francis, Heather, Kanno, Noriatsu, Chowdhury, Usha, Alpini, Gianfranco, LeSage, Gene

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

46

D2 but not D1 dopaminergic agonists inhibit secretory processes of the intrahepatic biliary epithelium through a PKC-dependent mechanism

Glaser, Shannon, Phinizy, Jo Lynne, Chowdhury, Usha, Kanno, Noriatsu, Francis, Heatber, Ueno, Yoshiyuki, Alvaro, Domenico, Lesage, Gene

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 201 KB

english, 2000

47

Inhibition of cholangiocarcinoma growth by tauroursodeoxycholic acid requires activation of cah2+ and protein kinase c (PKC) signaling pathways

Kanno, Noriatsu, Glaser, Shannon, Phinizy, Jo Lynne, Chowdhury, Usha, Francis, Heather, Alpini, Gianfranco, LeSage, Gene

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 196 KB

english, 2000

48

Efficacy of hepatitis C treatment is a function of ethnicity

Nguyen, Duke D.H., Basu, Dhiman, Clark, Cinda, Lesage, Gene

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

49

171 Loss of Nm23-H2 and Ncor Interactions with Peroxisome Proliferator-Activated Receptor δ (PPARδ) Promotes Cholangiocarcinoma Growth

Xia, Xuefeng, Zhang, Wenzheng, Venugopsl, Sushma, Xiao, Yuhua, Gao, Dongbing, LeSage, Gene

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 65 KB

english, 2008

50

Alpha-napthylisothiocyanate-induced cholangiocyte apoptosis is dependent on increased reactive oxygen species (ROS)

Lesage, Gene, Glaser, Shannon, Francis, Heather, Ludvik, Mikel, Phinizy, Jo Lynne, Kanno, Noriatsu, Alpini, Gianfranco

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 188 KB

english, 2001